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Senin, 01 Juli 2013

[H505.Ebook] Ebook Download Modern Prometheus: Editing the Human Genome with Crispr-Cas9, by James Kozubek

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Would you change your genes if you could? As we confront the 'industrial revolution of the genome', the recent discoveries of Crispr-Cas9 technologies are offering, for the first time, cheap and effective methods for editing the human genome. This opens up startling new opportunities as well as significant ethical uncertainty. Tracing events across a fifty-year period, from the first gene splicing techniques to the present day, this is the story of gene editing - the science, the impact and the potential. Kozubek weaves together the fascinating stories of many of the scientists involved in the development of gene editing technology. Along the way, he demystifies how the technology really works and provides vivid and thought-provoking reflections on the continuing ethical debate. Ultimately, Kozubek places the debate in its historical and scientific context to consider both what drives scientific discovery and the implications of the 'commodification' of life.

Sales Rank: #278381 in eBooks
Published on: 2016-09-30
Released on: 2016-10-07
Format: Kindle eBook

Review
"A solid introduction to the current state of affairs." (Science)�"A truly remarkable job of getting the nuances right, while dodging through the minefields between enthusiasm and easy dismissal." (George Church, Harvard)"A wonderful, rewarding and easily read book." (David Baltimore, winner of the Nobel Prize in Physiology or Medicine)"usefully pushes the discussion beyond obvious designer-baby concerns to the technique's limitations, and its broader implications for agriculture and the commercialization of science." (Nature)�

'Kozubek ... gives the general reader a solid introduction to the current state of affairs, as seen by its creators and those who are using it in research and commerce.' George J. Annas, Science

'... as eye-witness to a revolution in reading and writing our own genomes, [Kozubek] has done a truly remarkable job of getting the nuances right, while dodging through the minefields between enthusiasm and easy dismissal. Provides a rich tapestry of insights into the scientific discovery, technology development and applications to many agricultural,�environmental and medical problems which should matter deeply to all readers.' George Church, Harvard University

'Over the last 60 years the vast enterprise of experimental biology has taken the world from complete ignorance of how complex organisms are created to a very detailed knowledge of the processes involved. Now we are entering a world in which we can manipulate these processes, even modifying the heredity of our species and all others. James Kozubek tells the story of how we came to this knowledge in a carefully woven fabric of presentation, starting with the most recent events and then delving back into the history. He focuses on the remarkable personalities involved and the controversies that have complicated the discovery process. It is a wonderful, rewarding and easily read book.' David Baltimore, California Institute of Technology

About the Author
James Kozubek is a staff scientist at the Brigham and Women's Hospital with affiliation to the Broad Institute of Harvard University and the Massachusetts Institute of Technology. Kozubek is also an established journalist whose science writing has appeared in The Boston Globe, The Atlantic and Scientific American, amongst others.

Most helpful customer reviews

15 of 15 people found the following review helpful.
A comprehensive, up-to-date look at genetic modification
By Steve G
I enjoyed this book because it is an up-to-date look at genetic modification. It explains all the major methods including zinc finger technology, TALENS and CRISPR-Cas9. However, a prior knowledge of biology is required to understand a lot of what author Jim Kozubek discusses. His discussions are comprehensive and he gets a lot of his materials through interviews. This is very interesting but some of the quotes are so long I forgot who he was interviewing. Sometimes he goes into too much detail and I would see the trees, not the forest. Kozubek also takes several detours that detract from the book. His discussion of Chomsky was incomprehensible and his discussion of Mary Shelley was interesting but largely irrelevant. His dives into philosophy were equally unappealing. However his discussions of the potential for gene editing and the ethical and legal implications were very good. Overall, despite the faults, I can recommend this book to anyone with a background in biology who wants to learn more about the subject.
Disclosure: I received this book free via Netgalley in exchange for an honest review.

0 of 2 people found the following review helpful.
Compehensive, Great Effort
By Amazon Customer
Difficult, at times. A solid effort into some complicated terrain.

2 of 8 people found the following review helpful.
Ugh.
By Kindle Customer
Pretension + ADHD = a labyrinthine narrative.

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Rabu, 05 Juni 2013

[R654.Ebook] PDF Ebook Adventures in God, by John G. Lake

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Adventures in God, by John G. Lake

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John Graham Lake, (1870-1935), usually known as "John G. Lake", was a businessman influenced by the healing ministry of John Alexander Dowie, received the baptism of the Holy Spirit in 1907 in the wake of the Azusa Street Revival and became known for his ministry as a missionary and Faith Healer, where he saw tens of thousands healed either under his hands or those he trained. This book is his personal account in his own words. His testimonies of faith in the healing power of God and the wisdom of the Holy Spirit will challenge you to reach a new level in your spiritual walk.

Sales Rank: #1177224 in Books
Published on: 2013-07-19
Released on: 2013-07-19
Original language: English
Number of items: 1
Dimensions: 9.00" h x .12" w x 6.00" l, .18 pounds
Binding: Paperback
46 pages

Most helpful customer reviews

25 of 25 people found the following review helpful.
The Power of God Through The Amazing John G. Lake
By Peter Shultis
Read from the very hand of John G. Lake some of his incredible adventures with God. He gives great insight into his ministry. Of great interest is his 8 point commitment to the Lord. A key secret to the power of God operating through him was the deep level of personal integrity that Lake held himself to. Lake's accomplisments; like the establishment of 625 churches in Africa in just 4 years of ministry there. WOW This speaks to what the power of God will do from one ministry that flows in the miracle power of God. Lake is a man wonderfully unique, yet one who can be an example that challenges each of us. God can do the same things through you and me !

14 of 15 people found the following review helpful.
Faith lifting and compelling.
By A Customer
I found this small book to be very uplifting. John G. Lake was a gentle, loving servant of God. Who was used to perform unforgetable healings. Everywhere he ministered, God did miracles in the lives of those he prayed for. When Medical Science gave up on them, God intervined through the laying on of hands and they were healed. This book will build your faith. Don't miss reading it for yourself.

9 of 9 people found the following review helpful.
FAITH FOR FAITH
By Vanilla bee
John Grahamme Lake remains one of my fondest Apostlic ministers of the early 19th century. Just the revelation of compassionate faith that he shared in his time is something today's christian leader and indeed lay-man, can glean from. As you read this account you'll notice that the title is an accurate description of this man's experiences with God. He strongly believed that compassion is essentially linked with faith, especially in the areas of healing and deliverance; an ingridient that today's Tommy Tenney calls a 'Highly developed sense of injustice about satanic oppression'. Adventures in God is a very compelling and small volume sure to leave the reader wanting more, so if you would like to know more, there are excellent other books on John Lake and his teachings.

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Minggu, 02 Juni 2013

[W993.Ebook] Download PDF Concrete Pavement Design, Construction, and Performance, Second Edition, by Norbert J. Delatte

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This second edition of Concrete Pavement Design, Construction, and Performance provides a solid foundation for pavement engineers seeking relevant and applicable design and construction instruction. It relies on general principles instead of specific ones, and incorporates illustrative case studies and prime design examples to highlight the material. It presents a thorough understanding of materials selection, mixture proportioning, design and detailing, drainage, construction techniques, and pavement performance. It also offers insight into the theoretical framework underlying commonly used design procedures as well as the limits of the applicability of the procedures. All chapters have been updated to reflect recent developments, including some alternative and emerging design technologies that improve sustainability.

What’s New in the Second Edition:

The second edition of this book contains a new chapter on sustainability, and coverage of mechanistic-empirical design and pervious concrete pavements. RCC pavements are now given a new chapter. The text also expands the industrial pavement design chapter.

Outlines alternatives for concrete pavement solutions
Identifies desired performance and behavior parameters
Establishes appropriate materials and desired concrete proportions
Presents steps for translating the design into a durable facility

The book highlights significant innovations such as one is two-lift concrete pavements, precast concrete pavement systems, RCC pavement, interlocking concrete pavers, thin concrete pavement design, and pervious concrete. This text also addresses pavement management, maintenance, rehabilitation, and overlays.

Sales Rank: #2242034 in Books
Published on: 2014-05-22
Original language: English
Number of items: 1
Dimensions: 9.21" h x 1.00" w x 6.14" l, 1.70 pounds
Binding: Hardcover
445 pages

Most helpful customer reviews

0 of 0 people found the following review helpful.
A good textbook
By Lucio
A complete and updated review of concrete pavements.

0 of 0 people found the following review helpful.
Five Stars
By Amazon Customer
Excelent

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Minggu, 19 Mei 2013

[V273.Ebook] Ebook Download The White Rose, by Amy Ewing

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The compelling and gripping sequel to Amy Ewing's debut, The Jewel, which BCCB said "Will have fans of Oliver's Delirium, Cass's The Selection, and DeStefano's Wither breathless."

Violet is on the run—away from the Jewel, away from a lifetime of servitude, away from the Duchess of the Lake, who bought her at auction. With Ash and Raven traveling with her, Violet will need all of her powers to get her friends, and herself, out of the Jewel alive.

But no matter how far Violet runs, she can't escape the rebellion brewing just beneath the Jewel's glittering surface, and her role in it. Violet must decide if she is strong enough to rise against the Jewel and everything she has ever known.

Sales Rank: #73343 in Books
Published on: 2015-10-06
Released on: 2015-10-06
Original language: English
Number of items: 1
Dimensions: 8.25" h x 1.05" w x 5.50" l, .0 pounds
Binding: Hardcover
320 pages

From School Library Journal
Gr 9 Up—The sequel to The Jewel (HarperCollins, 2014) picks up within hours of the first volume's end. Violet and Ash's love affair has been discovered by the Duchess of the Lake. In order to save Ash and to survive, Violet must trust The Black Key, a secret society bent upon the destruction of the royals in the Jewel. Violet escapes from the Jewel circle to the Farm circle, along the way learning that surrogates are not the only ones who are being used by the royals: boys are forced to be companions for the wealthy, girls are being kidnapped into slavery, servants are killed on a whim, boys are being conscripted into military service, and children are dying from disease. This realization makes the protagonist determined to end the reign of the royals and discover the true meaning behind the Auguries, the powers that the royals find so desirable in their surrogates. What Violet learns about those powers will change the future of the city. This work has its own fast-paced plot and doesn't just bridge the first book to the third. Questions are answered from the first installment in this tale, backstory and history are provided for better understanding of the workings of the Lone City, and a surprise twist will make readers anxious for the next series entry. VERDICT A must-read for fans of the previous title; they will not be disappointed.—Lisa Nabel, Dayton Metro Library, OH

Review
“This fast-paced plot and a surprise twist will make readers anxious for the next series entry. A must-read for fans of the previous title; they will not be disappointed.” (School Library Journal)

“The story’s setting is interesting. A decadent matriarchal society is thought provoking. This is a quick read. Good storytelling.” (Voice of Youth Advocates (VOYA))

“Ewing bravely blends several genres. This solidly sets fans up for the next volume.” (Kirkus)

From the Back Cover

Violet is on the run. After the Duchess of the Lake catches Violet with Ash, the hired companion at the Palace of the Lake, Violet has no choice but to escape the Jewel or face certain death. So along with Ash and her best friend, Raven, Violet runs away from her unbearable life of servitude.

But no one said leaving the Jewel would be easy. As they make their way through the circles of the Lone City, Regimentals track their every move, and the trio barely manages to make it out unscathed and into the safe haven they were promised—a mysterious house in the Farm.

But there's a rebellion brewing, and Violet has found herself in the middle of it. Alongside a new ally, Violet discovers her Auguries are much more powerful than she ever imagined. But is she strong enough to rise up against the Jewel and everything she has ever known?

The White Rose is a raw, captivating sequel to The Jewel that fans won't be able to put down until the final shocking moments.

Most helpful customer reviews

9 of 10 people found the following review helpful.
Not as good as I hoped, but still an okay second installment. . .
By Alicia
3.5 STARS

THE WHITE ROSE was the highly anticipated sequel of THE JEWEL that I've been eagerly awaiting for months. And although it wasn't as good as I hoped it would be, it still had it's perks and has me eagerly anticipating the explosive conclusion I knows to come!

It was a lot slower paced then I would of liked. I mostly read fast-paced books with non-stop action and adventure, and though it did have it's moments with some action and adventure, it was no where near up to par with my standards. About the first half of the book had me contemplating putting it down. Like I said above, it did have mild action, but not the amount I hoped. And the first half was just Violet and her crew trying to make it out of The Jewel and to the farm where their sanctuary lied in The White Rose. And I got bored just having the story plotted around their travel. But once they finally did get to The White Rose it really picked up for me, and I started to enjoy it a lot more. Not that it's pace or action picked up, but the story unfolded and picked up it's plot, and I really got intrigued. And then that was when the magic began, and I was positively hooked. Violet's magic reveals itself and strengths tenfold from her capabilities in book one. And I really enjoyed the direction the plot took and is setting up for the finale in book three!!!

Another issue I had was the romance aspect. It felt strained and forced, and not the same sweet romance I enjoyed from book one. But surprisingly the lacking romance didn't really bother me that much. Ash was an okay love interest, I didn't really have anything against him, or any cause to love him either. But I still wanted more from the romance aspect. I would of liked more spark and chemistry, and though I appreciated that this book wasn't centered around romance like the first book was, but I still wanted more fire from their relationship and interactions. But I concede in a way it was understandable, because Ash and Violet were both going through their own struggles, and dealing with their own demons. So I guess it was okay for them to be a little distant in this middle book, but I expect more from their relationship in the next book!

What I really loved about this book was the fierce magic that was unleashed by the surrogates. It was breathtaking and beautiful to visualize the magical elements that was tapped into by the girls at The White Rose. And how they could make so many flowers grow, and then instantly die in a heart beat. How they could crack concrete, and then mend it back together with a flick of their wrist. It was exhilarating and riveting to watch all that power channeled with a force of magic that will hopefully become the savior of their world! And I can't WAIT to see all the surrogates come together and unleash all their power as one, and bring the end of the evil tyranny of The Jewel once and for all...

I also thought the writing Ewing created was alluring and descriptive, and was easily able to get lost in. The world-building was also a positive in this book. Since the first book I thought the setup of this world was different and intriguing. The circles of the standing classes, starting from the center where The Jewel lies, and the nobility rule, and working it's ways out from the ranks until you get the marsh, the lowest class in their system. And it was fascinating and intriguing, yet sickening and gruesome, how the nobility would use each lower class citizen, no matter their trade, gender or intelligence, and find some wicked way to use that person to their advantage, to help further their agendas regardless of what it was at the time.

THE PLOT

After being sold at the surrogate auction, and forced to give her body to the Duchess of the Lake, Violet thought their was no hope left. But when she meets Ash, a companion to the Duchess's niece, he changes everything and gives her a reason to keep fighting. But then when they're exposed, Ash is beaten and taken away to be murdered, Violet knows time is running out. And if she has any chance of saving Ash and making her planned escape on time, then she will have to form an unlikely alliance, before all is lost and she is forced to give birth to the Duchess's baby.

But making it out of the Duchess's clutches is only the first part of their journey. And Violet and her crew will have to travel through each circle, facing pursuit and unthinkable obstacles, if their going to make it to The White Rose where their magic can be awoken, and their fight to take back the lives that have been stolen from them will begin...

Sadly THE WHITE ROSE wasn't everything I hoped it would be, but still had it's parts that I really enjoyed. It lacked action and adventure throughout most of the book, and the romance was definitely on the back burner with no spark to ignite it. But regardless it was still there, and I have very high hopes that the next book will bring all that and some. But nevertheless, it still had an interesting plot with determined characters, and a magical background that later emerged and took this book to a whole new level, and has me desperately craving the next book in the series to see how it all plays out.

Overall, THE WHITE ROSE had aspects I loved and also hated, but was still a fun read that paints the path for book three, including all the twist and turns that I'm sure is to follow this epic cliffhanger ending. I think book three will definitely be the best in the complete trilogy, and I'm more then eager to find out! So if you enjoy a slower paced dystopian, with a back-burner romance, and a fantasy twist with magic, and determined characters, then THE WHITE ROSE may just be the sequel you were hoping for!!!

NOTE: I received a physical ARC from Harper Teen for reviewing purposes! All opinions expressed are my own and are not influenced in any way!

2 of 2 people found the following review helpful.
A great sequel!
By Teresa
This book picks up right where The Jewel left off and it gets going immediately. It is nonstop the whole time and I loved the pace of the book. There were no lulls or downtime and everything that happened was an integral part of the story. I enjoyed The Jewel but I reallllly enjoyed The White Rose.

I really like Violet as a character and I like how she has grown over the two books. She has grown into a strong character and I love her determination to fight and I love her loyalty to her friends even more. But I also love that she is realistic in that she does have doubts and moments where she doesn’t think she can do it and this is where the importance of her friends comes in. Because when she doubts herself, they are there to help pick her up and keep her going.

I also really came to love Ash in this book and their relationship. I really got the sense that while this is still new to them, they do love each other and their actions proved that beyond a doubt. Both of them have had rough lives and they understand that in one another. I also loved that they did argue and disagree, but those arguments never caused such a rift that they doubted one another, at the end of it all they knew they had one another. I love that Ash wants to fight and make a difference and I felt terrible when people continually overlooked him. But his time is coming, I can feel it.

And then we have Raven and Garnet. Raven is such a fantastic character and I adore her friendship with Violet. I am a big supporter of positive female friendships in YA and that is exactly what Violet and Raven have. And Garnet surprised me in this one and I’m definitely a big fan. He is quickly becoming one of my favorite characters in the series. Oh and Lucien. Lucien on the other hand is on my last nerve, I don’t care how smart he is or what he is doing, I wanna smack him.

Like I said, this one just keeps going from beginning to end and I really enjoyed that. And then the ending just drops on a dime and will leave you reeling for the next book. Waiting is really going to suck.

The White Rose is a good read and will keep readers addicted. If you want nonstop action, good characters, magic, and a truly dark and twisted world you should give this series a read.

4 of 5 people found the following review helpful.
A fast-paced, exciting, gripping, and tension-filled sequel
By Fiktshun
THE WHITE ROSE is fast-paced, exciting, gripping, and tension-filled. It picks up the story right where it left off after a cliffhanger ending that can only be called killer. It takes readers and characters alike on a nail-biting journey through other parts of the Lone City, reveals things about the surrogates and the royals that were previously unknown, sets the stage for an uprising, uncovers a sinister plan, and answers all those burning questions about the Auguries.

It is a sequel that delivers even more action than its predecessor. It’s a bit darker and more intriguing. It offers up details about the world, its history, its powers. It introduces new characters. It takes the story in a new direction. It is surprising, and fascinating, and immensely entertaining. It’s a suspenseful, edge-of-your-seat read that’s totally unputdownable.

Forced to flee the Jewel, Violet will have to put her trust in an unexpected ally if she wants to have any chance of making it to safety. She was supposed to have traveled alone but there was no way she was going to leave her friends behind. Even if it put her, put them all, in greater danger.

With no idea where she’s heading, or what she’s supposed to do once she gets there, Violet begins to question whether she made the right choice. But if the alternative is staying with the Duchess of the Lake, remaining property, being known only as Lot 197, facing the very real possibility of death, she doesn’t think she did choose wrong.

Even without a guarantee of safety, or freedom, or victory, the possibility of them all is worth every risk. She’ll just have to keep reminding herself of that fact when the Regimentals get too close, when the wanted posters plastered throughout every circle limit their chances of going undetected, when she learns what it is that’s expected of her.

Amy Ewing did an incredible job expanding on her story with this sequel, opening it up to new possibilities, exploring the history of the Lone City, sharing its darkest secrets, revealing the source of the Auguries’ power, changing up the setting, giving it a more focused purpose. She introduces some changes to her characters, making some more sympathetic, others stronger, others weaker, and others even more heartless than they’d been. She picks up the pace, ratchets up the danger, and adds in a number of surprises, producing a story that is absolutely riveting.

THE WHITE ROSE is a must for fans of the series, for readers who enjoy sequels that have substance, move the plot forward, improve upon the original, and that continue to astonish, thrill, enthrall. And with a jaw-dropping and somewhat abrupt ending, it will leave readers desperately awaiting the next installment.

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[W974.Ebook] Ebook The Hypnotic Salesman II: The World's Most Powerful Sales Persuasion Techniques, by Craig Beck

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Over a decade ago came the Hypnotic Salesman. Seven key principles of subliminal communication which teach anyone to sell directly to the subconscious, bypassing the part of the mind responsible for judging and evaluating.

Originally designed to give the sales executives of a major national commercial radio group the edge over their competitors, twelve years later the Hypnotic Salesman II drills down on the seven most powerful sales persuasion techniques in the world today. The secrets in this book will explode your closure rates, smash your targets and give you valuable insights into human motivation and persuasion.

Craig Beck will explain each principle in detail and then show you how, if you follow it directly with another you will create an unbreakable chain of events. Willpower and even a stubborn personality are no defense against these amazing but easily learned techniques.

What you will discover in this book will change and improve your interaction with everyone in your life. Not just with sales prospects but with your friends, family and partners too. People have used these techniques to blast their targets, improve their careers, understand their children better and even find and attract the man or woman of their dreams.

Sales Rank: #1344141 in eBooks
Published on: 2012-10-05
Released on: 2012-10-05
Format: Kindle eBook

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1 of 1 people found the following review helpful.
Every bit of information helps
By Michael J. Koepke
The Hypnotic Salesman II provides great incite into understanding the power of subconscious attraction. If you are in sales and who isn't, you must read this book.

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Rabu, 15 Mei 2013

[F958.Ebook] Download Ebook The Feasts of Memory: A Journey to a Greek Island, by Elias Kulukundis

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The Feasts of Memory is a book that inspires all those who left their homeland behind as well as those in search of new realms. Elias Kulukundis traces the course of a family’s emigration from Kasos island to Syros, the formerly commercial capital of Greece, and then from Syros to London and New York. He is equally at home describing expatriates around a dinner table in exile or delving into the motivating passions of the Aegean islands, some of them, in the words of The New Yorker Magazine, as savage as Homer's.

Elias felt he needed to write The Feasts of Memory in order to learn about himself. At the age of 29, he dramatized how a young Greek-American growing up on the edge of a golf-course in Westchester County could discover a spiritual connection to a barren island in the south Aegean Sea.

The Feasts of Memory is Elias’ narrative recreation on life on the island of Kasos, when both his grandfathers were sea-captains, and both his grandmothers were knobbly-handed island women who held house and home together while the men were away at sea.

The book captures the vivid and often eccentric characters and customs that ran through the family’s history, while it dramatizes the role of two of its most dominant women. The book is a stimulating combination of Mediterranean travelogue and the author’s autobiography as a ship owner and writer, seen through a collection of stories with wider historic and anthropological overtones. It creates a living picture of life in a Greek shipping family as it existed in the early twentieth century.

The book brings to life a world of ancient traditions and colorful customs that will inspire anyone wishing to discover Greece. It captures the nostalgia and excitement that accompany one’s search for origins as a key to one’s identity and meaning in life.

This edition includes a preface by the author and an expanded chapter with material about his late beloved cousin Michael Kulukundis, both written in 2013 specifically for this edition.

Sales Rank: #2787045 in eBooks
Published on: 2015-07-07
Released on: 2015-07-07
Format: Kindle eBook

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1 of 1 people found the following review helpful.
Musings on Kasos
By C. Moschopoulos
What a lovely book full of stories remembered and shared about the life on Kasos and the Kasoites. The myths and mythologies that we all embroider about our families and the past Mr Kulukundis uncovers about his. They are a feast to be savored, about things long gone but still in the memories of those who remained. How wonderful that the author was able to return to Kasos, his family's origin and record these stories before they were lost forever. He speaks of "xenitia" a Greek word and concept meaning in brief, homesickness. But as he explains it it is much more to the Greek than simply homesickness. It is a longing for the roots, for the homeland. So when one is uprooted from an island to Athens or from one island to another or from Greece to another country this creates 'xenitia', the longing. His own longing for his roots took him on a journey around the islands where his family originated and migrated. The book is a recounting of what he learned and experienced.

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Jumat, 03 Mei 2013

[D957.Ebook] Ebook A Science of Generic Design: Managing Complexity Through Systems Design, by John N. Warfield

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This text aims to simplify archaic, chaotic organisational structures by explaining how to analyse and design effective systems much needed in current government, business, industry, education, and other institutions of contemporary life. Important data and concepts are charted.

Sales Rank: #4099984 in Books
Published on: 1994-01
Original language: English
Number of items: 1
Dimensions: 11.50" h x 9.00" w x 1.50" l,
Binding: Hardcover
588 pages

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